Follicular Lymphoma Clinical Trials | A Drug Pipeline Analysis Report 2021 | DelveInsight

November 25, 2021

There are approximately 50+ key companies that are developing therapies for Follicular Lymphoma. Tisagenlecleucel and parsaclisib are in the most advanced stages of development, i.e. pre-registration.

/EIN News/ -- Los Angeles, USA, Nov. 24, 2021 (GLOBE NEWSWIRE) -- Follicular Lymphoma Clinical Trials | A Drug Pipeline Analysis Report 2021 | DelveInsight

There are approximately 50+ key companies that are developing therapies for Follicular Lymphoma. Tisagenlecleucel and parsaclisib are in the most advanced stages of development, i.e. pre-registration. 

DelveInsight’s “Follicular Lymphoma Pipeline Insight” report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in the Follicular Lymphoma pipeline landscapes. It comprises Follicular Lymphoma pipeline drug profiles, including clinical and non-clinical stage products. It also includes the Follicular Lymphoma therapeutics assessment by product type, stage, route of administration, and molecule type and further highlights the inactive Follicular Lymphoma pipeline products.     

Some of the key takeaways from the Follicular Lymphoma Pipeline Report  

Get an overview of pipeline landscape @ Follicular Lymphoma Clinical Trials Analysis 

Follicular Lymphoma is the most common type of low-grade non-Hodgkin lymphoma. It can develop at any age, but it is more common in people over 60.  

Follicular Lymphoma Emerging Drugs

·       Zandelisib: MEI Pharma
Zandelisib, an oral, selective PI3K delta (PI3Kδ) inhibitor, is being developed to treat follicular lymphoma and other B-cell malignancies. Zandelisib is being evaluated in multiple clinical studies, including COASTAL, a Phase III study, and TIDAL, a Phase II study, both of which are assessing zandelisib in patients with relapsed and refractory follicular and marginal zone lymphomas. The US FDA has granted zandelisib Fast Track designation. The development and planned commercialisation of zandelisib are being conducted in partnership with Kyowa Kirin Co., Ltd.. MEI and KKC will co-develop and co-promote zandelisib in the US, with MEI recording all revenue from US sales. KKC has exclusive commercialisation rights outside of the US.

·          Tafasitamab: Incyte corporation
Tafasitamab is a humanised Fc-modified cytolytic CD19 targeting monoclonal antibodies. In 2010, MorphoSys licensed exclusive worldwide rights to develop and commercialise tafasitamab from Xencor, Inc. In January 2020, MorphoSys and Incyte entered into a collaboration and licensing agreement to develop and commercialise tafasitamab globally. On January 7, 2021, the US FDA granted orphan drug designation to tafasitamab for the treatment of FL. It is currently being evaluated in the Phase III stage of development for the treatment of Follicular lymphoma.

·         Mosunetuzumab: Genentech
Mosunetuzumab (Anti-CD20 x CD3 TDB, RG7828) is a humanised full-length T cell-dependent bispecific antibody designed to target both CD20 on B cells and CD3 on T cells. This dual-targeting antibody is designed to redirect T cells to attack cancer cells. A Phase III clinical development programme for mosunetuzumab is ongoing, investigating the molecule as a monotherapy and in combination with other medicines for treating people with CD20-positive B-cell non-Hodgkin lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma, and other blood cancers.

·          Ublituximab: TG Therapeutics
Ublituximab (TG-1101) is an investigational glycoengineered monoclonal antibody that targets a unique epitope on CD20-expressing B-cells. When ublituximab binds to the B-cell, it triggers a series of immunological reactions (including antibody-dependent cellular cytotoxicity [ADCC] and complement-dependent cytotoxicity [CDC]), leading to the destruction of the cell. Additionally, ublituximab is uniquely designed to lack certain sugar molecules normally expressed on the antibody. It is currently being evaluated in a Phase II/III clinical trial.

·          Loncastuximab tesirine: ADC Therapeutics
Loncastuximab tesirine-lpyl is an ADC composed of a humanized monoclonal antibody that binds to human CD19 and is conjugated through a linker to a PBD–dimer toxin. ADC therapeutics is evaluating  Loncastuximab tesirine in Phase II clinical trials.

For further information, refer to the detailed report @ Follicular Lymphoma Pipeline Therapeutics 

Scope of Follicular Lymphoma Pipeline Drug Insight    

·       Follicular Lymphoma Therapies Late-stage (Phase III)  
·       Follicular Lymphoma Therapies Mid-stage (Phase II)
·       Follicular Lymphoma Therapies Early-stage (Phase I) 
·       Follicular Lymphoma Preclinical stage and Discovery candidates     
·       Discontinued and Inactive candidates  

·      Antibody-dependent cell cytotoxicity
·      Proto-oncogene protein c-bcl-2 inhibitors
·      Rad51 recombinase inhibitors
·      Phosphatidylinositol 3 kinase delta inhibitors
·      Phosphatidylinositol 3 kinase gamma inhibitors

·     Peptides
·     Monoclonal antibodies
·    Small molecules 
·    Recombinant protein 
·    Gene therapy

·     Parenteral 
·      Intravenous 
·      Oral
·      Subcutaneous
·      Topical

·       Monotherapy
·       Combination
·       Mono/Combination 

Key Questions regarding Current Follicular Lymphoma Treatment Landscape and Emerging Therapies Answered in the Pipeline Report  

Table of Contents

1 Follicular Lymphoma Report Introduction
2 Follicular Lymphoma Executive Summary
3 Follicular Lymphoma Overview
4 Follicular Lymphoma Pipeline Therapeutics
5 Follicular Lymphoma Therapeutic Assessment
6 Follicular Lymphoma – DelveInsight’s Analytical Perspective In-depth Commercial Assessment
7 Follicular Lymphoma Late Stage Products (Phase III)  
7.1 Zandelisib: MEI Pharma
8 Follicular Lymphoma Mid Stage Products (Phase II)
8.1 Loncastuximab tesirine: ADC Therapeutics
9 Follicular Lymphoma Early Stage Products (Phase I)  
9.1 ALLO-501: Allogene Therapeutics
10 Follicular Lymphoma Preclinical and Discovery Stage Products
11 Follicular Lymphoma Inactive Products
12 Follicular Lymphoma Key Companies
13 Follicular Lymphoma Key Products
14 Follicular Lymphoma Unmet Needs
15 Follicular Lymphoma Market Drivers and Barriers
16 Follicular Lymphoma Future Perspectives and Conclusion
17 Follicular Lymphoma Analyst Views
18  Appendix
19 About DelveInsight

Get a customized pipeline report @ Follicular Lymphoma Drugs Pipeline Report  

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